SONATA vs. PrimaryMD
Last updated . Pricing and features checked against both companies' public websites.
SONATA vs. PrimaryMD: Side-by-side comparison
| SONATA | PrimaryMD | |
|---|---|---|
| Membership cost | $2,500/year | $18,000/year |
| Blood biomarkers | 140+ biomarkers | 100+ markers |
| Blood draw | At home | At home |
| Follow-up testing | Six-month follow-up labs | Four draws a year, two comprehensive |
| Doctor appointments | Unlimited visits, same-day appointments | Same-day appointments, quarterly reviews |
| Care team access | 24/7 messaging via iMessage or email | Shared message thread with your team of four |
| Prescriptions | Yes, when clinically appropriate | Yes |
| Whole-genome sequencing | Included, 30x coverage | Included |
| Polygenic risk scores | 19 conditions | |
| Biological age | DNA methylation-based biological age and pace of aging | |
| DEXA and VO₂ max | Included in New York | Included twice a year |
| Personalized care plan | Built from your genes, labs, and history | One plan, led by your physician |
| Clinical AI | Built in-house for your doctors | |
| Urgent care | Sollis Health add-on, $3,120/year | Included through Sollis Health |
| Availability | New York, San Francisco, Los Angeles, Miami | Clinics in NYC and San Mateo; remote in LA |
Key takeaway
PrimaryMD ($18,000/year) is a physician-led primary care membership with clinics in New York City and San Mateo. It includes 100+ marker blood panels, whole-genome sequencing, DEXA, VO₂ max, a sleep study, and 24/7 urgent care through Sollis Health. SONATA ($2,500/year) includes 140+ biomarkers retested every six months, whole-genome sequencing, and biological aging analysis, with unlimited access to your physicians. DEXA and VO₂ max are included in New York.
Both sequence your genome. SONATA uses it to change your care, and its own engineering team builds clinical AI for its doctors.
PrimaryMD gives you a clinic and a longer testing menu. SONATA gives you care built for your biology, for a fraction of the price.
What are the biggest differences?
01SONATA offers the core testing for a fraction of the price
PrimaryMD charges $18,000 a year for four blood draws, one-time whole-genome sequencing, DEXA and VO₂ max twice a year, and a sleep study. Additional imaging costs extra. SONATA includes three layers of testing for $2,500 a year:
- 140+ blood biomarkers, retested every six months.
- Whole-genome sequencing, with polygenic risk scores for 19 conditions.
- DNA methylation testing for biological age and pace of aging.
Members in New York also get DEXA and VO₂ max included.
02SONATA builds your care plan based on your genetics
Both include whole-genome sequencing. PrimaryMD builds one plan on physician judgment across your history, labs, wearables, and imaging; it doesn't say how your genetics change it. At SONATA, your genome and history shape your care plan.
Take two people with the same cholesterol. If one has a higher inherited risk of heart disease, SONATA may set a lower ApoB target, start preventive medication, or order an earlier coronary calcium scan.
03SONATA's AI-empowered doctors
SONATA's clinical AI helps physicians connect thousands of research papers to your genetics, biomarkers, and history, work that could otherwise take days.
An in-house engineering team, led by a CTO who previously led engineering at Ramp, builds these tools and the member experience, from booking to iMessage. PrimaryMD doesn't list clinical AI.
04PrimaryMD has clinics and includes urgent care
PrimaryMD has clinics in Manhattan and San Mateo, pairs each physician with an exercise physiologist, care coordinator, and medical assistant, and includes 24/7 urgent care through Sollis Health. SONATA is virtual: same-day appointments, at-home blood draws, and 24/7 messaging via iMessage or email. It isn't urgent care, but members can add Sollis Health for $3,120 a year.
Which is right for you?
PrimaryMD may be a better fit if:
- You want a clinic to visit in New York or the Bay Area.
- You want a sleep study and an exercise physiologist included, or DEXA and VO₂ max outside New York.
- You want urgent care bundled into one membership.
SONATA may be a better fit if:
- You want the core testing for a fraction of the price.
- You want your genetics to shape your screening, treatment, and targets.
- You want doctors backed by clinical AI.
- You want same-day appointments and at-home blood draws, with urgent care as an optional add-on.
Frequently asked questions
The bottom line
SONATA gives you, for a fraction of the price:
- Core testing: 140+ biomarkers retested every six months, whole-genome sequencing, and biological age, all included.
- Care built on your genetics: your genes and history shape your targets, treatment, and screening.
- AI-empowered doctors: clinical AI, built in-house, connects the latest research to your biology.
- Care on your schedule: unlimited visits, same-day appointments, at-home blood draws, and 24/7 messaging via iMessage or email.
If you want a clinic, a sleep study, and urgent care in one $18,000 membership, PrimaryMD is a strong option. If you want a doctor who acts on your biology, SONATA does it for $2,500 a year.
Explore SONATA to learn more about its personalized approach to preventive care.
Sources
- SONATA. Homepage and pricing, What We Test, Personalized Care, FAQs.
- PrimaryMD. Membership (pricing and included diagnostics), How It Works, Locations.
- Sollis Health. Membership.
