SONATA vs. Biograph
Last updated . Pricing and features checked against both companies' public websites.
SONATA vs. Biograph: Side-by-side comparison
| SONATA | Biograph | |
|---|---|---|
| Membership cost | $2,500/year | $7,500 or $17,500 for the first year |
| Blood biomarkers | 140+ biomarkers | Advanced blood panel |
| Blood draw | At home | At the clinic |
| Follow-up testing | Six-month follow-up labs | Mid-year labs, Black tier only |
| Doctor appointments | Unlimited visits, same-day appointments | 6 or 13 scheduled touchpoints a year |
| Care team access | 24/7 messaging via iMessage or email | Ongoing access to the clinical team |
| Prescriptions | Yes, when clinically appropriate | Biograph Rx add-on, $82/month |
| Specialist coordination | Your physician refers and coordinates | Referrals for concerning findings |
| Genetic testing | Whole-genome sequencing, 30x coverage | Hereditary disease screening |
| Polygenic risk scores | 19 conditions | |
| Biological age | DNA methylation-based biological age and pace of aging | |
| Whole-body MRI | Member pricing on Prenuvo | Included |
| DEXA and VO₂ max | Included in New York | Included |
| Clinical AI | Built in-house for your doctors | In select imaging assessments |
| Availability | New York, San Francisco, Los Angeles, Miami | Clinics in NYC and San Mateo; virtual follow-ups |
Key takeaway
Biograph ($7,500 or $17,500 for the first year) is a diagnostic clinic: you spend one six-hour day in San Mateo or New York City for 20 to 30+ assessments, including whole-body MRI, DEXA, VO₂ max, and hereditary disease screening, then review the results with a physician a few weeks later. SONATA ($2,500/year) is year-round medical care: unlimited visits with your own doctors, 24/7 access, 140+ biomarkers retested every six months, whole-genome sequencing, and biological aging analysis.
Biograph says it complements your doctor rather than replacing one. SONATA is the doctor, and coordinates specialists and in-person testing when you need them.
Biograph gives you a deep snapshot. SONATA gives you a physician who acts on your biology all year.
What are the biggest differences?
01SONATA is ongoing care, not a testing day
Biograph's membership centers on one clinic visit. Your results review comes about three weeks later, followed by dietitian and exercise consultations and, on the Core tier, a year-end check-in. Black adds mid-year labs and a six-month check-in. Biograph counts 6 or 13 clinical touchpoints a year.
SONATA doesn't count visits. You get unlimited appointments with your physicians, same-day when you need them, and 24/7 messaging via iMessage or email. Labs are retested every six months with at-home draws, so your plan changes as your biology does.
02SONATA coordinates your care
Biograph doesn't replace your primary care physician. Ongoing medication management is a separate program, Biograph Rx, at $82 a month, and the team facilitates specialist referrals when a finding is concerning.
At SONATA, prescriptions are included when clinically appropriate, and your physician orders follow-up imaging, refers you to specialists, and keeps managing your care after the referral.
03SONATA builds your care around your biology
Biograph screens for hereditary cancer, cardiovascular, metabolic, and brain disease. SONATA sequences your whole genome at 30x coverage, adds polygenic risk scores for 19 conditions and DNA methylation-based biological age, and uses them to set your targets and screening.
Take two people with the same cholesterol. If one has a higher inherited risk of heart disease, SONATA may set a lower ApoB target, start preventive medication, or order an earlier coronary calcium scan.
SONATA's clinical AI, built by its own engineering team, helps physicians connect thousands of research papers to your genetics, biomarkers, and history. Biograph uses AI in select imaging assessments, such as coronary plaque characterization.
04Biograph includes deep imaging in one day
Biograph includes whole-body MRI, DEXA, and VO₂ max in Core, and adds coronary CT angiography, low-dose lung CT, a multi-cancer early detection blood test, and a brain health assessment in Black, all in one day. SONATA includes DEXA and VO₂ max in New York, offers member pricing on Prenuvo whole-body MRI and Galleri multi-cancer detection, and orders imaging when your risk calls for it.
Which is right for you?
Biograph may be a better fit if:
- You want whole-body MRI and cardiac CT included, done in a single day.
- You already have a doctor you trust for ongoing care.
- You can travel to San Mateo or New York City for the visit.
SONATA may be a better fit if:
- You want a physician you can see all year, same-day when needed.
- You want prescriptions and specialist coordination included, not added on.
- You want your genetics to shape your screening, treatment, and targets.
- You want labs retested every six months, drawn at home.
Frequently asked questions
The bottom line
SONATA gives you, for $2,500 a year:
- Ongoing care: unlimited visits, same-day appointments, and 24/7 messaging.
- Care coordination: prescriptions, specialist referrals, and in-person testing, managed by your physician.
- Care built on your biology: 140+ biomarkers retested every six months, whole-genome sequencing, and biological age, shaping your targets and screening.
- AI-empowered doctors: clinical AI, built in-house, connects the latest research to your biology.
If you want the deepest one-day imaging workup, Biograph is a strong option. If you want a doctor who acts on your biology all year, SONATA does it for $2,500.
Explore SONATA to learn more about its personalized approach to preventive care.
